Dear @Stephan Aal
Thank you so much for contacting Microsoft Q&A Forum.
Based on your description, it sounds like your Microsoft Access application using the Access Runtime, you need to ensure the application is located in a trusted location. Since runtime users can't access the Trust Center UI, this must be done via the Windows Registry. Access Runtime disables macros and VBA unless the database is in a trusted location. Without this, users will see security warnings, or the application may not function properly. Therefore, I recommend that you should manually or programmatically add a trusted location using the Windows Registry.
Kindly notes:
- Use the appropriate registry path depending on the version of Office installed.
- Machine-Wide Setup (Optional): if you want this to apply to all users on a machine, use HKEY_LOCAL_MACHINE instead of HKEY_CURRENT_USER.
Also, I have found several scenarios that have partially similar to your case and you can consult in there:
I hope this information can help you to finish this work.
Wish you a pleasant day!
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